I have always had a fairly regulated appetite and am within a healthy BMI, but since my Dr put me on Metformin 6 weeks ago 2x 500mg, I've noticed quite a bit of weight gain in my legs and stomach and an increase in appetite overall : (. I was fine when it was 1x 500, but I have been gaining weight on the adjustment. Using their understanding of clinical research, the authors recommended that the GLP-1 receptor agonists should be first-line therapy in type 2 diabetes. They invoke …Every single set of diabetes guidelines (the ADA, AACE, ACP, etc) puts metformin (the sole remaining drug in the "biguanide" class) as #1 amongst all those options. It's weight neutral (or even helps cause weight loss), super cheap, extremely effective, and typically very well tolerated (except for some transient nausea or diarrhea that for ...Insulin resistance, metabolic syndrome, obesity, fatty liver & the rest can be helped with lowering glucose. But nutrition & fasting is more powerful than Metformin. It does seem to help many people, but not so much if they have hyperinsulinemia & eat too often, eat too many carbohydrates.Metformin is not a direct route to increase fertility. It does help regulate your insulin which may result in a higher chance of pregnancy. I've been on it since 2015 and nothing hashappened to me expect a couple of stomach emergencies. Do your best to keep your blood sugars stable, inflammation down, and hydrated.The root cause of PCOS is insulin resistance, so that needs to be treated by metformin/Berberine, moderate gentle exercise, and a whole foods diet. The pill can actually make it way worse because it actually causes IR! MysiVlooi • 3 yr. ago.This study aims to investigate the effect of metformin on hippocampal and cortical volumes in non-demented diabetic individuals. We entered 157 non-demented diabetic subjects including 89 mild cognitive impairment (MCI), and 68 cognitively healthy individuals from Alzheimer's disease Neuroimaging Initiative (ADNI) which …Also PCOS and nondiabetic. The metformin is used to help regulate my hormones/cycles. It's been a godsend. Just make sure to know the signs and symptoms of hypoglycemia- the meds main job is to help lower blood sugar, if it drops too low it can be dangerous- I've had an easier time regulating it with the protein on keto.A website’s welcome message should describe what the website offers its visitors. For example, “Reddit’s stories are created by its users.” The welcome message can be either a stat...Berberine seems better for directly working on increasing insulin sensitivity, which then helps lower blood sugar indirectly. Metformin on the other hand seems to lower blood sugar better than berberine, though it may not be as good at increasing insulin sensitivity directly. I still feel low key hunger on metformin, though it's still better ... There's no known serious long term effects of metformin use. There's some possible effects, but what is speculated has not had any direct links with metformin use itself. Being that it's a pretty old drug, and is considered a first line medication for the treatment of insulin resistance, it's pretty well studied for safety. SummerJinkx. Oct 25, 2565 BE ... Metformin has helped me so much and I've only been on it a short time! I'm losing weight, feeling more energetic and “normal”. I had absolutely ...Nov 17, 2566 BE ... Metformin will mess up your guts don't be embarrassed. When I first went on it I had the soupy poopies something fierce. That's the unfortunate ...I personally have never had any issues drinking while on metformin. But I also havent had any adverse reactions to metformin in general. To he safe, id say just take it slow if youre going to drink. Id try to avoid getting super wasted just to be on the safe side, but I think youll be okay either way. Icy-Thanks-3170.Metformin may cut the risk of long covid, especially if taken early. May I share with you all this latest randomized controlled trial on metformin. Hopefully more good news to come in the near future. Locked post. New comments cannot be posted. The people in the study had obesity. There might not be a direct correlation, since …Metformin's got a lot of possible mechanisms and we don't understand any of it fully. One interesting part is that it might work via AMPK which you'll be interested in if you listen to Rhonda Patrick.. Its biggest risk might be cognitive impairment: Metformin linked to increased risk of dementia and Parkinson's and Increased Risk of Cognitive Impairment …Oct 7, 2565 BE ... Metformin was a godsend for me, I was never able to lose weight before it, now I've lost 40lb over 10 months! I got nausea and diarrhea that ... The literature suggests Metformin is a useful, simple option for antipsyhotic induced gain weight. My question is, do you use it in your practice? And if so, when do you start it? When you notice the patient is gaining weight or preemptively when you initiate an antipsyhotic known for this? (eg. olanzapine) Sort by: Add a Comment. View community ranking In the Top 1% of largest communities on Reddit. Metformin and inhibition of gluconeogenesis: is it safe ... "This redox-dependent mechanism would also explain why metformin treatment is rarely associated with hypoglycemia given that gluconeogenesis will never be totally inhibited. "Discover how the soon-to-be-released Reddit developer tools and platform will offer devs the opportunity to create site extensions and more. Trusted by business builders worldwide,... Yes, I have experience with metformin and it does help you lose weight as long as you are on a LC diet, you can achieve even better results if you combine metformin with acarbose. My recommendation is as follows: Eat 6gr of carbohydrates during breakfast and 12gr of Carbohydrates during lunch and dinner. View community ranking In the Top 1% of largest communities on Reddit. Metformin and inhibition of gluconeogenesis: is it safe ... "This redox-dependent mechanism would also explain why metformin treatment is rarely associated with hypoglycemia given that gluconeogenesis will never be totally inhibited. "Of course it's similar to fasting. But I think you're better off eating less than with metformin. Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older …I've read that metformin can be used to treat Pre-diabetes and insulin resistance. The literature is promising as I have reviewed many studies posted online. While the ADA actually recommends this as a treatment, the FDA has not approved any drug for IR / Pre-diabetes. The information is largely split down the middle (pro/con) on the subject, I ... Alternative to metformin, preferably injectables. Prediabetic. Hi all, I was just diagnosed with pre-diabetes, and after a week on Metformin I can't tolerate it. The acid reflux was getting better until last night, when it came back with a vengeance, along with really bad nausea, stomach pain, a terrible metallic taste and a sore tongue (which ... Reddit, often referred to as the “front page of the internet,” is a powerful platform that can provide marketers with a wealth of opportunities to connect with their target audienc... The literature suggests Metformin is a useful, simple option for antipsyhotic induced gain weight. My question is, do you use it in your practice? And if so, when do you start it? When you notice the patient is gaining weight or preemptively when you initiate an antipsyhotic known for this? (eg. olanzapine) Sort by: Add a Comment. Jan 31, 2567 BE ... I got my 500mg Metformin mixed up with my 750mg and accidentally took 3000mgs a day for two weeks. My blood sugar was excellent, down to 90 ...Discover how the soon-to-be-released Reddit developer tools and platform will offer devs the opportunity to create site extensions and more. Trusted by business builders worldwide,...reply. My doc suggested taking Metamucil two hours after the metformin to help with GI issues. It worked. Nah, I take it twice a day and it's fine. Been on it for 20+ years. No side effects that I’ve noticed. I went from 500 mg a day to 2000 mg in a day in one week. I am the opposite, now I can't go the bathroom. The metformin i got to help me regulate hormones and loose weight. I started with 500mg and whent up to 2000mg over 1,5 months. The first few days after incresing I have had nausia. but it passed after 2-3 days. Also i have been tired. I have finaly started loosing weight. 5-6kg the last 1,5 months. I think this helped me get back into the habit of a full 7-8 hour night of sleep. I also started working out consistently shortly after this post. I would wake up early before work and get 30-45 min on my exercise bike. I think this helped to exhaust me physically. It might also be helpful to take your metformin earlier. The ethics are that nobody would get hurt from such things but you, so you have total license to act. Ethically, one absolutely never has a duty to follow immoral (or even amoral) laws. Legally, however, you absolutely have a duty to follow such laws. Decide which is more important, but for me to avoid potentially becoming a victim of your ... Metformin is designed to help the insulin you are currently making, absorb into the cells. Since Type 1s make ZERO insulin, it’s a waste to take it. Type 2 benefits as their body still produces insulin yet struggles to process it, enter Metformin.Roger that, thanks, ChiknRice • 1 yr. ago. Improves insulin sensitivity and allows more energy going into cells for recovery, as well as more energy while working out as it allows for more proteins and carbs to enter the muscles. Good for bulking, and should add fullness.In July my a1c was 6.3% so i was diagnosed with prediabetes. My primary put me on extended release metformin at 500mg. I wasnt given any info about the drug or what I can do to prevent my diagnosis from progressing so I've had to rely on the internet (bad decision b/c every site says something completely different). ADMIN MOD. [Compound Experience Saturday] Metformin. Compounds. For those unaware, each week we have a specific steroid or PED up for discussion. This week we are discussing Metformin. The goal of these threads is to generate discussion about the posted compound and get a wide variety of user experiences and feedback about it. METFORMIN AND BERBERINE COMPARISON. Been on metformin for about a fortnight and built to one tablet in the AM and one in the PM now seem to be getting headaches every day. Looked into Berberine as a natural alternative, seems like its got general good reviews. Is there anyone out there who has used berberine and …For example, one could take metformin to moderate the BG numbers while continuing to eat carbs/sugar just worsening an insulin sensitivity problem and the descent into a worsening problem. Or one could take it along with proper diet and exercise to keep BG numbers very nice and low which probably at least increases the odds of not sliding further.Nov 8, 2566 BE ... The most common medications providers prescribe for prediabetes are metformin and acarbose. Care at Cleveland Clinic. Diabetes Care · Make an ...31 upvotes · 1. r/diabetes. Screenshot from my self-developed diabetes management system: In about 7 months, my trend line shows that my diabetes management regime is working, although there is still room for improvement. Thanks to everyone here and elsewhere for all the advice and help! 30 upvotes · 9 comments. r/diabetes.People on Metformin have reported having a green to yellowish color. If your stool turns a dark color, it's a sign of blood in your stool. never happened to me after 10+ years and going...only occasional diarrhea. Thanks for all the answers! This community is very helpful. I get the loose stool with it.View community ranking In the Top 1% of largest communities on Reddit. Metformin and inhibition of gluconeogenesis: is it safe ... "This redox-dependent mechanism would also explain why metformin treatment is rarely associated with hypoglycemia given that gluconeogenesis will never be totally inhibited. "If you think that scandalous, mean-spirited or downright bizarre final wills are only things you see in crazy movies, then think again. It turns out that real people who want to ma... Just recently diagnosed with PCOS and my Dr is putting me on Met, 500mg (ER) to assist with weightloss and PCOS symptoms. I am 5ft7 and 244lbs. I was on strict keto since January 2018 and all I could lose was 10lbs. Extremely frustrating. I would like to hear from people on 500mg and who are losing weight, with or without diet/excercise. I have always had a fairly regulated appetite and am within a healthy BMI, but since my Dr put me on Metformin 6 weeks ago 2x 500mg, I've noticed quite a bit of weight gain in my legs and stomach and an increase in appetite overall : (. I was fine when it was 1x 500, but I have been gaining weight on the adjustment. Metformin and stomach issues. Hey! I was recently diagnosed with DT2 with an A1c 9.7 😢 doctor prescribed 2 gr of metformin daily and advised me to start gradually and now I’m taking the two pills however is making me sick with diarrhea and nausea, I noticed this when I started to take the second pill. I also had IBS before so it’s …Once flying high on their status as Reddit stocks, these nine penny stocks are falling back towards prior price levels. These Reddit stocks are falling back toward penny-stock pric...Reddit is a popular social media platform that boasts millions of active users. With its vast user base and diverse communities, it presents a unique opportunity for businesses to ...I take metformin for PCOS (insulin resistance) which can lead to type 2 diabetes. I lost my sugar cravings on metformin and without any changes to food or exercise (except for the fact that I naturally wanted less sweets) I dropped 30lbs in about 3 months.Reddit is a popular social media platform that boasts millions of active users. With its vast user base and diverse communities, it presents a unique opportunity for businesses to ...... metformin intoxication to validate this clinical ... metformin (4 to 8 g) and five were not ( ... Share on Reddit. Get shareable link. Other Actions.It also has been documented to help with fertility and healthy pregnancy outcomes in PCOS populations. Berberine hasn’t been quite as extensively studied as inositol but there growing research on it also bodes well for its efficacy compared to metformin. It also has been found to be less harsh in terms of side-effects.Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American …They say Contrave is contraindicated for those with anxiety disorder, and they freaking mean it. I briefly discussed Metformin with my doctor, but given the amount of weight I needed to lose (~100 lbs), my doctor and I decided it would be better to go with Contrave. Metformin can actually make one gain weight. Depends.One of metformin's mechanisms for reducing incidence of some cancers is the desensitization of GH receptors. This creates some fear on whether using it could be more detrimental than benefitial to bodybuilders. However, an abstract of a meeting from the Endocrine Society points out that only high dose metformin has these effect, while also ... Yes, I have experience with metformin and it does help you lose weight as long as you are on a LC diet, you can achieve even better results if you combine metformin with acarbose. My recommendation is as follows: Eat 6gr of carbohydrates during breakfast and 12gr of Carbohydrates during lunch and dinner. Increase your carb amount and try to eat those whole grains and vegetables. If you’re getting nausea, try an antihistamine to make sure it’s not a psychological kinda nausea, or lower your dosage of met and increase it slower. If you’re getting heart burn, reflux, etc, limit your citrus and acidic foods. Metformin is a drug for managing blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it … Good sleep and regular exercise have worked better than anything else I've seen or tried. However, metformin is very safe. There's a reason it is first line treatment for T2DM. One should take it with meals to reduce the diarrhea effect it can have, but besides that it is relatively well tolerated. Apr 24, 2565 BE ... About a week for me. 1000mg x 2 a day. Taking with food helps. But it was a week for hell and it will still happen if I eat a lot of fruit / ...Woah, metformin really works. (review) I've been recently diagnosed with lean PCOS and although I was technically "lean" as my BMI was 20 and I wasn't overweight, I've always been trying to lose weight. When my PCOS was rampant I was at 60kg, 168cm, and I felt bloated + had a face full of acne. (I'm asian so any excess weight goes straight to ...Metformin makes people age more slowly. Example of research: "Emerging evidence indicates that metformin has favorable effects on health beyond those associated with improvement in glycemia. Observational studies suggest that diabetic individuals treated with metformin manifest a survival benefit even when …Every single set of diabetes guidelines (the ADA, AACE, ACP, etc) puts metformin (the sole remaining drug in the "biguanide" class) as #1 amongst all those options. It's weight neutral (or even helps cause weight loss), super cheap, extremely effective, and typically very well tolerated (except for some transient nausea or diarrhea that for ...They are for blood sugar control. Higher doses of ozempic for weight loss are off label use, this is still a diabetic drug. Ozempic causes your body to release more insulin when necessary, but metformin makes your body more sensitive to insulin, thus bringing down fasting insulin and requiring your body to produce less of it to get a normal ... GI problems started as soon as I was taking the 2 pills of metformin a day + paxlovid. Inhad the worst diarrhea and was nauseous the entire day. So I stopped metformin. I ended up getting covid rebound 4 days after my last dose of paxlovid. I do not know if metformin helps prevent rebounds. If they did and I knew it, I would've continued the ... Metformin works in the colon so that is why most people get upset stomach and diarrhea w cramping. I had to start very, very slow. Regimen that I recommend to patients is start 250 mg at bedtime every NIGHT or every other night. Wait 10 days to increase because used stomach starts a few days into regimen.Woah, metformin really works. (review) I've been recently diagnosed with lean PCOS and although I was technically "lean" as my BMI was 20 and I wasn't overweight, I've always been trying to lose weight. When my PCOS was rampant I was at 60kg, 168cm, and I felt bloated + had a face full of acne. (I'm asian so any excess weight goes straight to ...On a more serious note, it's bullshit. If metformin was a miracle drug it would be very widely known and publicised as its been studied since the 50's. There are no drugs like that. I am not an expert, but new benefits of old drugs are discovered all the time. In fact, metformin's itself has come in and out of favor repeatedly due to changing ... Increase your carb amount and try to eat those whole grains and vegetables. If you’re getting nausea, try an antihistamine to make sure it’s not a psychological kinda nausea, or lower your dosage of met and increase it slower. If you’re getting heart burn, reflux, etc, limit your citrus and acidic foods. Metformin will not cause a weight loss, it will merely make the fat loss possible. It's up to you to do dietary changes to lose weight. Look up in this subreddit what exactly to do, but basically - a lot of fibre and greens, 1-1.3g of protein per kg of body mass, some healthy fats (20g?), no carbs added if possible.Aug 16, 2566 BE ... Maybe time for a new doctor. What are you doing diet and exercise wise to stop your a1c from going higher? Three successive A1Cs that are ... After four months of diet and exercise I had lost 13 kg and was no longer prediabetic, so she took me off metformin. I continued to lose weight (15 more kg) unmedicated with normal sugar levels and controlled PCOS. I do believe that metformin helped me in the first part of my journey by managing my insulin resistance. After-Swordfish-5603. •. I also just got prescribed topiramate and metformin as well! When I did weight loss meds before through my docs office, I was prescribed topiramate and phentermine and I lost 14lbs in a few months on both. However then I noticed the effects started to wear off and I was back to boredom eating. Metformin made me beyond exhausted. I’d sleep 16 hours a day and the rest of the time was too tired to get off the couch. All my hormone and vitamin levels were perfect, so no issue with low b12, low iron, low thyroid, etc. It was 100% the Metformin. Within 2 days of stopping all of my energy came back. Side effects included: extreme diarrhea, headaches, nausea, stomach pains, brain fog, a feeling of brain fuzziness (like pins and needles but sometimes sharper), and probably other things I've blocked out of my mind at this point because it was the worst month of my life. 14 votes, 30 comments. true. Hi! I just started metformin Wednesday, so we’re twins! I have a 2000 mg rx, but doc told me to start at 500, up to 1000, up to 1500, up to 2000 basically once the smaller dose felt comfortable. I took 500 on Wednesday and Thursday and had no real issue other than kinda what you described. Type 2. I wanted to share my personal experience with Ozempic vs. Metformin to see if anyone else has similar results. For a couple of years I'd been taking Metformin and had good results. In particular, with regular exercise, normal weight, and fairly strict control of my diet, I had achieved an A1C level of 6.4 as of December 2022.It is shown that metformin can increase serotonin levels and thus regulate mood, but I think that one of the main reasons for positive effects on anxiety and mood is mainly to better regulation of insulin and glucose levels. Also, metformin will at least in first couple of weeks disrupt the way your digestive system works, and being that it is ...The studies he's done show that there are several things that have a significant impact on this kind of healthy longevity - including growth hormone, cholesterol, and mitochondrial peptides. He also suggests that metformin, a diabetes medication, could be a powerful tool for slowing down age-related decline.Switching to ER Metformin went from impossible to sort of workable, but I was still vomiting at least once a week. When I got health insurance I switched to non-generic Metformin and that eliminated the vomiting enough that I could actually take the full dosage. Unfortunately taking 2000 mg daily is how I discovered I can't handle it...Things that control blood glucose via the same mechanisms will have similar hormesis-reducing effects. Although the AMPK activation from berberine is less than metformin. I personally use and really like berberine/DHB. Haven't noticed any decreases in endurance or lactate tolerance as is commonly reported with metformin. GI problems started as soon as I was taking the 2 pills of metformin a day + paxlovid. Inhad the worst diarrhea and was nauseous the entire day. So I stopped metformin. I ended up getting covid rebound 4 days after my last dose of paxlovid. I do not know if metformin helps prevent rebounds. If they did and I knew it, I would've continued the ... Metformin does have some adverse reactions. Diarrhea, flatulence, vomiting and nausea are common early reactions but no more usual in t1 than t2. Vitamin B12 deficiency is another one. Some very uncommon serious reactions are megaloblastic anemia, lactic acidosis, and hepatic toxicity. Metformin plus sulfonylureas vs. glucagon-like peptide-1 receptor agonists All-cause mortality: 1.15 (0.49 to 2.67) Metformin plus sulfonylureas vs. dipeptidyl-peptidase-4 …I was diagnosed in November and started in late Nov/early Dec 2023 and am taking 1000mg daily. I’ve lost ~10lbs since I started. I have always been pretty active 3-5 days a week … Metformin increases lactic acid levels at rest. This seems to be because metformin is actually a mitochondrial toxin. This is the reason why Peter Attia stopped metformin use. Metformin blunts some of the beneficial responses to exercise (esp. the upregulation in anti-oxidant systems). From what I've read, viewed and experienced, it's normally an incremental dosage. First week, 500mg, second, 1000mg, third to 1500 and fourth to 2000 with each week checking for adverse side effects reporting negatives to your doc. Regardless, always check with your doctor on dosages and side effects as well as interactions with currently ... Aug 20, 2565 BE ... Type 2 Diabetes drug Metformin may protect the aging brain from atrophy in elderly individuals with diabetes based on a study of 157 people.Metformin may decrease vitamin B12 levels and increase levels of homo‐cysteine, leading to higher cardiovascular risk. In a trial where 196 patients received a mean dose of Metformin of 2.1g homocysteine increased by an average of 0.40 μmol and vitamin B12 decreased by 4.40 pmol.Metformin reddit
I have a shit tonne of energy. Abdominal pain is listed as a side effect. Some people just can’t adjust to metformin. You may need a combo drug or ask about Forxiga. I took that (I’m now in a combo forxiga/metformin) and it worked well for me. (FTR I …I think this helped me get back into the habit of a full 7-8 hour night of sleep. I also started working out consistently shortly after this post. I would wake up early before work and get 30-45 min on my exercise bike. I think this helped to exhaust me physically. It might also be helpful to take your metformin earlier.At my levels a change of -18 would be pretty significant. For higher carb meals that might push me down from 155 -> 137, which is below the 140 cutoff for neuropathy. Small changes and after six months of Metformin twice a day, my …The studies he's done show that there are several things that have a significant impact on this kind of healthy longevity - including growth hormone, cholesterol, and mitochondrial peptides. He also suggests that metformin, a diabetes medication, could be a powerful tool for slowing down age-related decline.He previously was taking tradjenta 5mg and is currently on both. He was put on the Metformin because his A1C went from 7 to 9 over the last 15 months, and his diet wasn’t exactly being controlled and he wasn’t exercising much either. His glucose was averaging around 250-280mg/ml each day before Metformin, having hit a …The most common side effect of metformin use is gastrointestinal, i.e, heartburn, gas, nausea, diarrhea, which to me are potentially unpleasant enough to preclude its use as a "longevity" drug in otherwise healthy people w/ normal blood glucose function. Still, metformin is one of the safer drugs to take, much safer than OTC NSAIDs.Metformin —> Berberine. My doctor switched me from Metformin (500mg bid) to Berberine (500mg tid) because I need to get my blood sugar under control and I cannot tolerate the Metformin (stomach pain, diarrhea). Only side effects from the Berberine (I’m on Day 5) are soft stool and peeing all the damn time.The studies he's done show that there are several things that have a significant impact on this kind of healthy longevity - including growth hormone, cholesterol, and mitochondrial peptides. He also suggests that metformin, a diabetes medication, could be a powerful tool for slowing down age-related decline.Yes, aging. If that's true, "wonder drug" might be an understatement. What is metformin? The history of metformin goes back hundreds of years. In Europe, the …One of metformin's mechanisms for reducing incidence of some cancers is the desensitization of GH receptors. This creates some fear on whether using it could be more detrimental than benefitial to bodybuilders. However, an abstract of a meeting from the Endocrine Society points out that only high dose metformin has these effect, while also ...Make sure you're taking it with food. Your doctor should have started you on a low dose to build your tolerance. For example, 500mg once a day for a week, then 500mg 2x a day. Then blood work after a certain amount of time to see if you need a higher dose. At that point, if increased, 1000mg in am, 500 at night for a week, then 1000mg 2x a day.It took me a few months off metformin plus weekly B12 injections to get my levels back to normal. I feel so much more energized and alert now. shamanixx. • 6 yr. ago. Now that you mention it, I really do remember experiencing brain fog the year I was on Metformin. Its crazy to see this thread!Make sure you're taking it with food. Your doctor should have started you on a low dose to build your tolerance. For example, 500mg once a day for a week, then 500mg 2x a day. Then blood work after a certain amount of time to see if you need a higher dose. At that point, if increased, 1000mg in am, 500 at night for a week, then 1000mg 2x a day.Metformin tried to kill me via my liver/liver enzymes- my main symptoms were severe fatigue and feeling like I swallowed tacks for hours after each dose… progressed after only a week into thinking I had kidney stones coming on, only it was a significantly enlarged liver.Metformin Dosage for Weight Loss. How Effective Is Metformin? Is Metformin Better for Weight Loss Than Ozempic? Is Long-Term Weight Loss Possible …I’ve been on it for a couple of months now and I still find it really hard to eat. It’s not just that I don’t have an appetite either, but that not many foods even taste good to me anymore. :/ I find myself repulsed a lot of the time. I was on metformin once before for almost a year and never had this issue, but this time seems to be ... The studies I have read involving NAC as a metformin substitute for people with PCOS took it in addition to Inositol so don't forget to use that too. I used this combination for about 3 months before I found the supplements were just prohibitively expensive for me. The studies show that it takes at least 6 months of this regimen to show ... View community ranking In the Top 1% of largest communities on Reddit. Metformin and inhibition of gluconeogenesis: is it safe ... "This redox-dependent mechanism would also explain why metformin treatment is rarely associated with hypoglycemia given that gluconeogenesis will never be totally inhibited. "I do take it in the evening, so if my body wants to flush out anything (and sometimes it does) it’s not really a problem. I did start with 1000mg and worked my way up to 2000 mg though. Keeper504. • 1 yr. ago. Yes the extended release has been better for myself. I actually take Janumet XR (Januvia/Metformin XR).Things that control blood glucose via the same mechanisms will have similar hormesis-reducing effects. Although the AMPK activation from berberine is less than metformin. I personally use and really like berberine/DHB. Haven't noticed any decreases in endurance or lactate tolerance as is commonly reported with metformin.This study aims to investigate the effect of metformin on hippocampal and cortical volumes in non-demented diabetic individuals. We entered 157 non-demented diabetic subjects including 89 mild cognitive impairment (MCI), and 68 cognitively healthy individuals from Alzheimer's disease Neuroimaging Initiative (ADNI) which …I was put on Metformin immediately after being diagnosed with diabetes (assumed Type II) at age 32. A1C at 7.8, fasting glucose 200. After a week, it was increased to 1000mg per day. Dropped back to 500mg once in the morning per doctor's order after 1 month due to significant drop in weight and A1C. The first 5 months were constant anxiety. I’ve heard of cases where people didn’t have a great reaction to metformin but saw better results on inositol. I’ve seen a few indicate the reverse. Plenty of people take the both together. I think it really varies from person to person but I read a recent meta-analysis that suggests that—at least in the short term—most people do well ... Hi Reddit, (to whom I owe the greatest of debts for the incredible support since my Type 2 dx.) ... Metformin is a slow/long acting drug: it has very little immediate impact on your blood glucose levels. So you can take it whenever you like: ...Reddit is not the only company launching ways for communities to host conversations. Reddit announced Thursday that it is testing Discord-like chat channels with select subreddits....Apr 24, 2565 BE ... About a week for me. 1000mg x 2 a day. Taking with food helps. But it was a week for hell and it will still happen if I eat a lot of fruit / ... After four months of diet and exercise I had lost 13 kg and was no longer prediabetic, so she took me off metformin. I continued to lose weight (15 more kg) unmedicated with normal sugar levels and controlled PCOS. I do believe that metformin helped me in the first part of my journey by managing my insulin resistance. Been on Metformin for 4 years- consistent diarrhea and loose stools. I was diagnosed as type 2 in April 2015. I cannot honestly remember the last time I had a normal stool. I consistently either have diarrhea or very loose stools. My doctor prescribed me 1000mg twice daily and I'm fairly certain they're NOT the extended release as my medicine ...What to Know Before You Take It. Are you struggling to lose weight? Metformin can do more than improve blood sugar control — it may also help you lose …METFORMIN AND BERBERINE COMPARISON. Been on metformin for about a fortnight and built to one tablet in the AM and one in the PM now seem to be getting headaches every day. Looked into Berberine as a natural alternative, seems like its got general good reviews. Is there anyone out there who has used berberine and …The root cause of PCOS is insulin resistance, so that needs to be treated by metformin/Berberine, moderate gentle exercise, and a whole foods diet. The pill can actually make it way worse because it actually causes IR! MysiVlooi • 3 yr. ago.I have a shit tonne of energy. Abdominal pain is listed as a side effect. Some people just can’t adjust to metformin. You may need a combo drug or ask about Forxiga. I took that (I’m now in a combo forxiga/metformin) and it worked well for me. (FTR I …Yes, aging. If that's true, "wonder drug" might be an understatement. What is metformin? The history of metformin goes back hundreds of years. In Europe, the … However, after 1 month of treatment, a significant decrease in total, free, and bioavailable testosterone was observed in the metformin group compared with baseline levels (P <.05). No significant decrease was observed in the control group.”. Testosterone increases at first then drops after a month. Berberine is a dupe for metformin so I think it’s worth a shot. Metformin did not help my hair loss. It has helped with some reactive hypoglycemia. I tried Spiro! Zero Success it gave me the dread shed and I stopped it a few days ago after 6 …Like a couple of others mentioned, I was told to take a b-complex to offset what metformin depletes. In general, my fatigue before metformin was helped by taking a b12 supplement. I think is also depletes Vitamin D and sweet baby Jesus if my Vit D dips just a little bit I can't get out of bed and function as a human.Undervalued Reddit stocks continue to attract attention as we head into the new year. Here are seven for your perusal. Tough economic climates are a great time for value investors ...Alternative to metformin, preferably injectables. Prediabetic. Hi all, I was just diagnosed with pre-diabetes, and after a week on Metformin I can't tolerate it. The acid reflux was getting better until last night, when it came back with a vengeance, along with really bad nausea, stomach pain, a terrible metallic taste and a sore tongue (which ... The studies I have read involving NAC as a metformin substitute for people with PCOS took it in addition to Inositol so don't forget to use that too. I used this combination for about 3 months before I found the supplements were just prohibitively expensive for me. The studies show that it takes at least 6 months of this regimen to show ... InvestorPlace - Stock Market News, Stock Advice & Trading Tips If you think Reddit is only a social media network, you’ve missed one of... InvestorPlace - Stock Market N...Insulin resistance, metabolic syndrome, obesity, fatty liver & the rest can be helped with lowering glucose. But nutrition & fasting is more powerful than Metformin. It does seem to help many people, but not so much if they have hyperinsulinemia & eat too often, eat too many carbohydrates.I had issues with low/zero appetite after starting Metformin. It got better gradually over a period of a few weeks and mostly went back to normal (except with fewer bouts of getting “hangry”/ravenous at the drop of a hat because my blood sugar had dropped).Apr 6, 2566 BE ... Yes, if you go to a pharmacy (hopefully the a different location of the one you use) speak to the pharmacist. If it's in the US, they should be ...Metformin is not a direct route to increase fertility. It does help regulate your insulin which may result in a higher chance of pregnancy. I've been on it since 2015 and nothing hashappened to me expect a couple of stomach emergencies. Do your best to keep your blood sugars stable, inflammation down, and hydrated.Apr 14, 2565 BE ... Metformin and prediabetes · Your doctor will tell you if you need to increase the metformin. I was on 500mg of metformin for awhile and it was ...T1 for 32 years and insulin resistance building. Metformin had little to no effect on me (including the side effects). What has worked incredibly well is Ozempic. TDD instantly dropped around 40% and I've lost 14kg (31lb) of weight that the resistance built and would not let me lose - that's in 12 weeks.I think this helped me get back into the habit of a full 7-8 hour night of sleep. I also started working out consistently shortly after this post. I would wake up early before work and get 30-45 min on my exercise bike. I think this helped to exhaust me physically. It might also be helpful to take your metformin earlier. 1. m540nightowl. • 3 yr. ago. The max dosage of Metformin ER in a day is 2250 mg and for regular Metformin it is 2500 mg. Most over dosages for any medication are usually well above the max dosage and max dosages are for a 150lb male. If you weigh to more than that you can usually take a larger dosage of just about any medication. Oct 25, 2565 BE ... Metformin has helped me so much and I've only been on it a short time! I'm losing weight, feeling more energetic and “normal”. I had absolutely ...Reddit, often referred to as the “front page of the internet,” is a powerful platform that can provide marketers with a wealth of opportunities to connect with their target audienc...Reddit announced Thursday that it will now allow users to upload NSFW images from desktops in adult communities. Reddit announced Thursday that it will now allow users to upload NS... Metformin does have some adverse reactions. Diarrhea, flatulence, vomiting and nausea are common early reactions but no more usual in t1 than t2. Vitamin B12 deficiency is another one. Some very uncommon serious reactions are megaloblastic anemia, lactic acidosis, and hepatic toxicity. . Bang muay thai